This article reviewed the aspects of the comprehensive, multi-disciplinary lactation program implemented in one large neonatal intensive care unit. The program included the implementation of centralized handling with dedicated technicians of all human milk and formula feedings as well as bar code scanning within the preparation room and at bedside. Other program initiatives included use of a bedside lactation care algorithm, staff training, use of a lactation bundle for families, and funding for a home freezer program. This lactation program was found to be successful in increasing breastfeeding rates in the NICU; however, this study found that the COVID-19 pandemic did impact the program outcomes.